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Misha had a pretty busy Comic Con this year.  He's been in political activist mode of late, using his connection with a young fandom to encourage them to exercise their right to vote and make a difference in this country.  He took some time during the panel to pass our voter registration cards.  He believes (rightfully so) that young people are an ignored demographic and need to make their voices heard. 
In both Alice's and Nightksy's interviews, Misha talked a bit about his activties and his hopes for mobilizing the youth of America.  He also talked a bit about Castiel too, since yeah, he's got that other job too.  :)
Warning! There are some spoilers here, especially in Alice's interview
Here is Alice's interview with Misha, which was her last of the day:
And here's Nightsky's interview, her first of the day: