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"That was funny, John. We're going to flay the skin from your bones, but that was funny." Meg, "Salvation"
Meg was just the queen of snark. There were tons of lines to choose from because her delivery after the demon reveal was just brilliant. But this was my favorite one. She's snarky and menacing all in one.
"Oh, my god! That painting looks so good." Sam, "Provenance"
This makes me laugh every time I hear it. Sam is rightfully surprised to see that hideous painting again after he and Dean burned it up. He's just so caught off guard, and watching him try to lie his way through the situation is funny.